Optiferrin – Defined, Animal-free, Recombinant Human Transferrin.
Most effective way to deliver iron in cell culture without any oxidative reactions or cell damage caused by other iron sources.
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Optiferrin is recombinant human transferrin that is completely animal component free. Optiferrin's performance is equivalent to human transferrin in cell culture and offers significant regulatory advantages due to its safety and consistency. Optiferrin is produced in an animal-free system (see ExpressTec), which eliminates safety concerns associated with animal or human derived transferrin that can cause contamination with viruses and prions. In addition, Optiferrin is a consistent product with none of the lot-to-lot variability seen in other transferrins and is an excellent animal-free replacement for bovine transferrin and plasma-derived human transferrin.
As a universal iron carrier, Optiferrin also provides better performance than other iron sources and iron chelators. All cells need iron for cell division and transferrin is specifically designed to deliver iron to the cells. Each cell has transferrin receptors that ensure optimal iron delivery based on the actual iron need of the cells. The cells decide how much iron they need, thus eliminating the problem of too much iron causing cell damage. The problem with alternative iron sources and iron chelators is that cells cannot regulate the amount of iron that is delivered and studies have shown that cells can take in 100 times physiological intracellular iron. The uptake of too much iron causes significant cell damage and other iron sources can cause oxidative damage which also causes cell damage; neither of these types of damage can occur when transferrin is used.
Research & Production Cell Lines
Stem Cell & Regenerative Medicine Cell Lines
HL-60 (promyelocytic leukemic) cells in medium supplemented with Optiferrin grew equal to or better than the same medium supplemented with human plasma transferrin.
Optiferrin increases hybridoma productivity. Antibody concentrations are shown in a 6-day batch culture of hybridoma cells.